Ulusu lwePU alunabungozi kumzimba womntu. Isikhumba se-PU, ekwabizwa ngokuba yi-polyurethane yesikhumba, yinto eyenziwe ngethwathwa eyenziwe nge-polyurethane. Ngaphantsi kokusetyenziswa okuqhelekileyo, i-PU yesikhumba ayikhuphi izinto ezinobungozi, kwaye iimveliso ezifanelekileyo kwiimarike ziya kuphinda ziphumelele uvavanyo ukuze kuqinisekiswe ukhuseleko kunye nokungabikho kwetyhefu, ngoko inokugqithwa kwaye isetyenziswe ngokuzithemba.
Nangona kunjalo, kwabanye abantu, ukunxibelelana kwexesha elide kunye ne-PU yesikhumba kunokubangela ukungakhululeki kwesikhumba, njengokurhawuzelela, ubomvu, ukudumba, njl. Ukongeza, ukuba ulusu luvezwe kwi-allergen ixesha elide okanye isigulana sineengxaki zobuntununtunu bolusu, kunokubangela ukuba iimpawu zokungakhululeki kwesikhumba zibe mandundu. Kubantu abaneemigaqo-siseko ye-allergies, kucetyiswa ukuba ugweme ukudibanisa ngokuthe ngqo kwesikhumba ngokusemandleni kwaye ugcine iimpahla zicocekile kwaye zomile ukunciphisa ukucaphuka.
Nangona i-PU yesikhumba iqulethe iikhemikhali ezithile kwaye inefuthe elithile elicaphukisayo kwi-fetus, ayisiyonto enkulu ukuyiphunga ngamaxesha athile ixesha elifutshane. Ke ngoko, kubafazi abakhulelweyo, akukho mfuneko yokuba ukhathazeke kakhulu malunga nokunxibelelana kwexesha elifutshane kunye neemveliso zesikhumba zePU.
Ngokubanzi, isikhumba sePU sikhuselekile phantsi kweemeko eziqhelekileyo zokusetyenziswa, kodwa kubantu abanovelwano, kufuneka bathathelwe ingqalelo ukunciphisa ukudibanisa ngokuthe ngqo ukunciphisa ingozi enokwenzeka.